Man United saw off rivals Liverpool in a classic meeting in the last stage to secure their place in the fifth round, while West Ham dismissed League One opponents Doncaster 4-0.
The two Uniteds last came up against each other in the FA Cup in 2016, with a 1-1 draw at Old Trafford in the sixth-round tie preceding Man United’s 2-1 victory in the replay at Upton Park – the last ever FA Cup match at the Hammers’ old stadium.
Here’s everything you need to know about the fifth-round meeting.
The game will kick off at 7.30pm this evening.
The match will air live on BBC One in the UK.
For Man United, Phil Jones remains a long-term absentee following his knee surgery, while fellow centre-back Eric Bailly is a doubt after he sustained a knock last week. Paul Pogba went off injured against Everton and could miss out here as a result.
Man United: Henderson; Wan-Bissaka, Lindelof, Maguire, Shaw; Fred, McTominay; Rashford, Fernandes, Greenwood; Cavani
West Ham: Fabianski; Fredericks, Dawson, Diop, Cresswell; Soucek, Rice; Bowen, Lanzini, Fornals; Yarmolenko
This seems like a great opportunity for West Ham to go for it with little inhibition, with an ‘upset’ certainly possible. But Man United’s strength in depth might just be the crucial difference here. Man United 2-1 West Ham.