Mr Biden made the comments against the fellow Democrat appearing in an interview on ABC New as calls for the governor’s resignation have grown louder.
When asked whether Mr Cuomo should resign if investigations confirm the allegations, the president replied said “Yes, I think he’ll probably end up being prosecuted, too.”
Seven women have accused Mr Cuomo of sexual harassment since February. The governor denied the allegations but apologised for “making anyone feel uncomfortable.”
A number of fellow Democrat politicians, including Senate majority leader Chuck Schumer and Senator Kirsten Gillibran, have joined the chorus to demand Mr Cuomo’s resignation.