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Southampton will be just as keen to end their poor run of results, having lost their past three league matches.
Ralph Hasenhuttl has plenty of injury problems too, so it could be an uphill task, although he will be encouraged by their positive performance against Aston Villa last time out, despite the result.
Here is everything you need to know.
Manchester United vs Southampton takes place tonight, Tuesday 2 February.
How can I watch on TV and online?
The game will be broadcast live in the UK on BT Sport. Customers can stream the match online via the BT Sport website and the BT Sport app.
United may mix up their defence as Victor Lindelof continues to manage an ongoing back injury, which may see Eric Bailly return to the side.
Saints are set to be without Theo Walcott, Ibrahima Diallo and Oriol Romeu through injury, while Kyle Walker-Peters and Jannik Vestergaard remain out.
Manchester United: De Gea, Wan-Bissaka, Bailly, Maguire, Shaw, Fred, Matic, Pogba, Rashford, Bruno Fernandes, Martial
Southampton: McCarthy, Ward-Prowse, Bednarek, Stephens, Bertrand, Redmond, Djenepo, Jankewitz, Armstrong, Ings, Adams
Manchester United need to bounce back after recent struggles and we expect them to do just that against a depleted Southampton. Manchester United 2-1 Southampton.
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